Climate change over High Mountain Asia is investigated with CMIP6 climate models. A general cold bias is found in this area, often related to a snow cover overestimation in the models. Ensemble experiments generally encompass the past observed trends, suggesting that even biased models can reproduce the trends. Depending on the future scenario, a warming from 1.9 to 6.5 °C, associated with a snow cover decrease and precipitation increase, is expected at the end of the 21st century.